Telomeres and longevity
نویسندگان
چکیده
منابع مشابه
Telomeres and longevity
the basic elements of telomere biology are very similar across many taxa [1], there is diversity among species, and among tissues, in telomere dynamics. Not surprisingly, given that species differ in many other relevant aspects of their biology, including the pattern of activity of the telomere-restoring enzyme telomerase simple comparisons of average telomere length across species do not map d...
متن کاملTelomeres, Atherosclerosis, and Human Longevity
Human telomere length, as expressed in leukocytes, is strongly fashioned by heritability. A number of genes that explain some of the inter-individual variation in leukocyte telomere length have already been identified. Leukocyte telomere length is longer in women than in men and in African Americans than in whites of european descent. in addition, offspring of older fathers display a longer leu...
متن کاملTelomeres and longevity: testing an evolutionary hypothesis.
Identifying mechanisms that underlie variation in adult survivorship provide insight into the evolution of life history strategies and phenotypic variation in longevity. There is accumulating evidence that shortening telomeres, the protective caps at the ends of chromosomes, play an important role in individual variation in longevity. Given that telomeres generally shorten with age, it was surp...
متن کاملShort Telomeres in Hatchling Snakes: Erythrocyte Telomere Dynamics and Longevity in Tropical Pythons
BACKGROUND Telomere length (TL) has been found to be associated with life span in birds and humans. However, other studies have demonstrated that TL does not affect survival among old humans. Furthermore, replicative senescence has been shown to be induced by changes in the protected status of the telomeres rather than the loss of TL. In the present study we explore whether age- and sex-specifi...
متن کاملThe rate of increase of short telomeres predicts longevity in mammals.
Aberrantly short telomeres result in decreased longevity in both humans and mice with defective telomere maintenance. Normal populations of humans and mice present high interindividual variation in telomere length, but it is unknown whether this is associated with their lifespan potential. To address this issue, we performed a longitudinal telomere length study along the lifespan of wild-type a...
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ژورنال
عنوان ژورنال: Aging
سال: 2012
ISSN: 1945-4589
DOI: 10.18632/aging.100437